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Propose sessions and covered subjects

Propose sessions and covered subjects

Part A: Basic Mechanobiology
I  Biophysics and Molecular Biology of force sensing and generation
   1) Mechanosensing molecules:  Channel type and non-channel type mechanosensitive proteins
   2) Force generating molecules: Biophysics of force generation in actomyosin system, flagella, cilia
   3) Biophysics and mechanics of organelle:  Membrane, cytoskeleton, nucleus, membrane fusion
   4) Biophysics and Biomechanics of protein folding
         5) Experimental methods in Mechanobiology: Mechanical manipulation of single molecules (laser tweezers, AFM), visualization of stress and strain in molecules, lab on chip, nano- & micro-fluidics
   6) Theoretical and model approaches: Molecular Mechanics, mesoscopic model, finite element model
   7) Dynamics of bio-macro-molecular configuration under force action
   8) Molecular and biochemical mechanisms of mechanosensing and mechanoenzymatic functionality
II  Cell Biology of shape, migration, proliferation and differentiation
   1) Cell shape and migration: Mechanical regulation of shape and migration
   2) Cell volume regulation: Regulated volume increase and decrease (RVI & RVD)
   3) Cell adhesion and migration: integrins, selectins, immunoglobulin superfamily and chemokine
4) Proliferation: Role of cell-cell and cell-substrate contacts
   5) Differentiation: Mechanical regulation of cell differentiation in stem cells
   6) Signaling: Mechano-specific cell signaling (Ca2+, kinase, phophatase, etc.)
   7) Transcription and expression: Mechanical regulation of gene expression, role of mechanical stress in neuclei
III  Physiology of specialized mechanoreceptors
   1) Inner ear: Mechanotransduction in hair cells
   2) Skin: Tactile sensation at skin receptors
   3) Muscle: Muscle spindles and tendon organs,
   4) Stretch receptors: carotid sinus baroreceptors, intestine, bladder
   5) Pain, nociceptor, and mechanotransduction

Part B: Applied Mechanobiology
IV  Mechanobiology in medical physiology:
   1) Mechanical regulation of cardiac function: Mechano-electic feedback, Straling’s law
2) Mechanical regulation of vascular functions: Stretch and shear stress sensing and signaling in endothelial cells
3) Mechanical regulation of pulmonary functions: Responses of alveolar epithelium and airway smooth muscle to mechanical stress
4) Mechanical regulation of bone metabolism: Osteoblasts and osteoclasts
5) Biorheology of blood flow and erythrocytes
V  Mechanobiology of diseases
   1) Cardiac hypertrophy, Atrial fibrillation
   2) Hypertension and Atheroscrelosis
   3) Coagulation and Thrombosis
   4) Muscle atrophy and dystrophy
   5) Osteoporosis
   6) Mechanobiology of inflammation
   7) Mechanobiology of cancer
  8) Mechanobiology of aging
VI  Mechanobiology of medical treatments
   1) Mechanobiology of wound repair of skin tissue
   2) Mechanobiology of tissue regeneration including bone repair
   3) Mechanobiology of arterial stent, artificial heart and vessel
   4) Mechanobiology of orthodontic tooth and distraction osteogenesis
   5) Mechanobiology of artificial joint
   6) Mechanobiology of physical therapy
 VII  Special topics
   1) Gravity sensing in animals and plants
   2) Mechanobiology in plants and protozoa
   3) Mechano-induced ATP release as an extracellular mechanosignaling
   4) Mechanobiology in Sports medicine
   5) MicroRobotics and mechanobiology
   6) Tribology and mechanobiology
   7) Mechanobiology and Medicine in astronautics
VIII  Other topics in biophysicsmechanobiology and biomechanics



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